FMT Method

Fecal Microbiota Transplant (FMT) is a procedure in which faecal matter, or stool, is collected from a tested donor, mixed with a saline or other solution, strained, and placed in a patient, by colonoscopy, endoscopy, sigmoidoscopy, or enema. The procedure is a way of implanting the beneficial intestinal bacteria and yeasts from a healthy donor into the gut of a person who is lacking the essential Microflora they need for their gut to function properly. The purpose of faecal transplant is to replace good bacteria that has been killed or suppressed, usually by the use of antibiotics, causing bad bacteria, like Clostridium difficile (C. diff), to over-populate the colon. Faecal Microbiota Transplant (FMT) is also known under the following names: • Human Probiotic Infusion • Faecal Bacteriotherapy • Microbiota Restoration Therapy Faecal Microbiota Transplant (FMT) is a more refined version of an earlier therapy known variously as: • Faecal Transplant • Faecal Transfusion • Faecal Enema • Stool Transplant

What is Faecal (Faecal) Microbiota Transplant used for?

Whilst large-scale trials data exists only for Clostridium difficile, recent and on-going academic and medical research indicates that gut bacteria may play a significant part in modifying or treating the symptoms of: • Clostridium difficile infection • Inflammatory Bowel Diseases (Crohn’s Disease & Ulcerative Colitis) • Irritable Bowel Syndrome - IBS (Post-Infectious, Post-Antibiotic) • Irritable Bowel Syndrome - IBS-Constipation, IBS-Diarrhoea, IBS-Mixed • Obesity • MS (Multiple Sclerosis) • CFS (Chronic Fatigue Syndrome) • RA (Rheumatoid Arthritis) • Autism

What’s it like to receive a Fecal (Faecal) Microbiota Transplant?

Well, few medical treatments are fun, but we do try to make ours as easy on our patients as possible. The treatment is not painful or uncomfortable. We treat all our patients as outpatients, so as soon as you’re done at the clinic for the day you can go home or back to your hotel to relax. We advise lots of rest and relaxation during the program. The number of recommended treatments varies according to the condition you’ve been diagnosed with. Each treatment session lasts between 90 minutes and 3 hours. Generally, the more severe your symptoms are when you come to us, the longer your session will last. We’ve developed our own method of transplanting via rectal catheter which avoids the intrusive and often uncomfortable use of a colonoscope. We appreciate that some of our patients have been very ill for a long time before they find us so we’ll make every effort to be gentle with you and you’ll have all the time you need.

How is the implant made?

Making the best possible implants is a big part of our research here at the CIBS. The process starts with a healthy donor. We test our donors thoroughly and screen for a wide range of diseases. We ask them to follow a specific diet devised by us to ensure that their gut contains the optimum range of microbiota. Many of the microbiota important to good gut health don’t survive long when exposed to oxygen or other environmental factors so we collect the donor material under deoxygenated conditions and transport it back to the lab in an insulated container along with a sterile saline solution. Once back in the lab, the sample is processed at a controlled temperature and nitrogen-rich environment to separate the microbiota you need from the food waste element of faeces that you don’t need. We then make up the implants, which we fast freeze under lab conditions for later use; we don’t use them until we have re-tested the donors to ensure the continuing safety and quality of the implants.

To discuss whether FMT might be appropriate for you please call on 03 9331 3122 or email [email protected]